MIPS 25th Anniversary Profile: BioSurface Engineering Technologies–spinal fusion using a novel peptide

Project Manager:  Paul O. Zamora;  Principal Investigator:  Joseph Byrant, UMBI
Location:  Rockville, Maryland – Montgomery County;  Project Start Date:  2/1/2007

Pictured: Dr. Paul Zamora, Vice President and Chief Scientific Officer, BioSET

Business Description
BioSurface Engineering Technologies specializes in implantable orthopedic products. The company is developing proprietary therapeutic peptides for incorporation into medical devices to improve bone and soft tissue repair. BioSET’s synthetic peptides are bioactive mimetics of growth factors that continue to show promising results in studies for the treatment of musculoskeletal, vascular and chronic wound diseases. The company plans to capitalize on the growing interest in drug/device combination products and seeks to initiate studies of these combination products in human clinical trials.

Challenge
BioSET sought to test its Amplex medical device product for inducing spinal fusion in the lumbar region in a pre-clinical study.

MIPS Role
Dr. Joseph Bryant from [then] UMBI’s Institute of Human Virology used an in-vivo model to evaluate and compare the efficacy of Amplex versus an autograft alone for lumbar spinal fusion. The ingrowth characteristics of these two procedures was compared using radiography, biomechanics, and histology.

Results
The results of this study, along with ongoing biocompatibility, safety, and manufacturing validation led to the submission of an IDE (Investigational Device Exemption) for Amplex to the U.S .FDA in 2007. BioSET reported one new hire, $1.2M in revenue and $556,000 in grants attracted as a result of its MIPS project.

BioSet is a graduate of Mtech’s Technology Advancement Program incubator.

Leading up to (and beyond) the Maryland Industrial Partnerships (MIPS) 25th Anniversary Gala, each weekday we will briefly profile one (or more) of the 500+ companies that have utilized MIPS funding to bring innovations to market and create jobs in Maryland.

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